Written by Fred Cicetti Wednesday, 11 June 2008 05:19
A Although genetics is important in Parkinson disease, many researchers believe environmental exposures also increase a person’s risk of developing the disease. Studies show that farmers and other agricultural workers have an increased risk of getting PD.
PD was first described in 1817 by James Parkinson, a British physician. It affects one in 100 people over age 60. It can also affect younger people. The average age of onset is 60. Research suggests PD affects at least 500,000 people in this country.
PD is a complex disorder of the central nervous system. It is the second most common neurodegenerative disease in the United States, after Alzheimer’s.
Defining symptoms of PD include tremor, slow movement, rigidity and impaired balance and coordination. As symptoms become more pronounced, patients may have difficulty walking, talking or completing simple tasks. They also may experience depression, difficulty sleeping and other problems.
The progression of symptoms in PD may take 20 years or more. In some people, however, the disease progresses much more quickly.
In the early 1960s, scientists determined that the loss of brain cells was causing PD. The cells that were depleted produced dopamine, a chemical that helps control muscle activity. Today, PD is treated with drugs and surgery.
Medications for PD fall into three categories.
drugs that increase the level of dopamine in the brain.
medications that affect neurotransmitters in the body to ease some of the symptoms of the disease.
substances that help control the non-motor symptoms of the disease such as depression.
There are two commonly used surgical treatments for PD—pallidotomy and deep brain stimulation. Because these procedures are invasive, they are usually reserved for severely afflicted Parkinson’s patients who do not get adequate relief from medications.
Surgeons discovered that by removing or destroying parts of the brain that were “misfiring,” some of the symptoms of PD could be alleviated. One of these operations is pallidotomy.
Scientists have found that they can mimic the effects of pallidotomy by deep brain stimulation. With DBS, an electrode is implanted in the brain in a way that calms the abnormal neuronal firing. DBS is now the primary surgical intervention for PD.
A wide variety of complementary and supportive therapies may be used for PD. Among these therapies are standard rehabilitation techniques which can help with problems such as gait and voice disorders, tremors and rigidity and cognitive decline. Exercise may help people improve their mobility.
While Parkinson’s is a complex disease, research has progressed a great deal in recent years. Halting the progression of PD, restoring lost function and even preventing the disease are now considered realistic goals.
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